Epitalon 1mg

Epitalon (AEDG) synthetic tetrapeptide research compound (Ala-Glu-Asp-Gly). Subject of studies exploring telomerase activation and telomere maintenance.

Epitalon (AEDG) Tetrapeptide Bioregulator | Stateside Bio Research

Epitalon (AEDG) is a synthetic pineal tetrapeptide (C₁₄H₂₂N₄O₉), approximately 390 Da. This low molecular weight is a factor in research focusing on oral bioavailability for compound delivery.

Core Research Mechanisms:

• Telomere Dynamics: Confirmed hTERT activation and telomere elongation in human somatic cells; independently verified in human fibroblast and epithelial lines.

• Epigenetic Regulation: Binds to DNA/linker histones, regulating chromatin architecture and transcription in aged lymphocyte cultures. Regulates neuronal differentiation gene expression in human stem cells.

• Neuroendocrine Signaling: In senescent rhesus monkeys (Macaca mulatta), administration stimulated evening melatonin production and normalized the circadian cortisol rhythm.

Preclinical & Clinical Findings:

Preclinical data show maximum lifespan extension of 42% in CBA mice and 11-16% in Drosophila melanogaster.

Limited human investigations (using Epitalon or Epithalamin):

• A 15-year cardiovascular study reported a significant reduction in cardiovascular mortality risk and 26.7% improvement in 15-year survival in elderly patients.

• A clinical investigation reported a 90% positive clinical effect in human patients with degenerative retinal lesions (retinitis pigmentosa).